usually air finds its way to the highest radiator ( not always tho) so that its usually one radiator that requires bleeding, a pressure system/combi system will need pressurising as you bleed the radiators and may need doing several times over a few days because the air is being carried around the system especially when switched on for the first time after summer. note that your boiler may cut out and show a fault as the pressure falls during bleeding, to prevent this whilst bleeding keep an eye on the pressure gauge which is usually just under the boiler itself and once its at 1 barg stop bleeding and pressurise the system again, keep doing this until you cant hear air being expelled from the vent point. If your boiler does cut out and goes into low pressure fault, the fault should clear once pressure is built up again.